SRMS JOURNAL OF MEDICAL SCIENCE 2022-03-28T23:23:05+0530 Pradeep Tiwari Open Journal Systems <p>The SRMS Journal of Medical Sciences (SRMSJMS) is a biomedical journal with national circulation. It publishes original communications of biomedical research that advances or illuminates medical science or that educates the journal readers. It is issued six monthly, in two volumes per year.&nbsp;Manuscripts dealing with clinical aspects will be considered for publication, provided they contain results of original investigations. Articles need to be of general interest - e.g., they cross the boundaries of specialities or are of sufficient novelty and importance that the journal's readers, whatever their speciality, should be made aware of the findings. Research papers reporting original research, review articles, correspondence on published articles will also be considered. Papers of routine nature which are merely records of interesting cases as also those dealing with modifications of routine methodology will not be encouraged.</p> <div class="page-header"> <h1>Article Processing Fee/Open Access Fee</h1> </div> <p><strong>Author Fee</strong></p> <p>Indian Journal of Pharmaceutical and Biological Research is an open access journal, and then Author submission, as well as article processing and publishing, is&nbsp;<strong>free of charge</strong>.</p> <p>Readers can read and download any full-text articles for&nbsp;<strong>free of charge</strong>.</p> COMPARISON OF STATURE AND FOOT LENGTH IN ADULTS IN SRMSIMS BAREILLY 2022-03-28T23:23:05+0530 Priyanka Chahal Jaswinder Singh <p class="p1">Introduction: Estimation of stature plays an important role in forensic anthropometry as it</p> <p class="p1">helps in estimating the identity of an individual. Many studies for estimating the stature from</p> <p class="p1">measuring long bones, with derivation of formulas are there. The present study is an attempt to</p> <p class="p1">evaluate a possible correlation between stature of an individual and foot length in adults.</p> <p class="p1">Material and Methods: A sample of 100 medical students; 50 males &amp; 50 females studying in</p> <p class="p1">Shri Ram Murti Smarak Institute of Medical Sciences was considered &amp; measurements were</p> <p class="p1">taken for height and foot length.</p> <p class="p1">Results: It was found that both the parameters showed a correlation with each other. <span class="s1">The</span></p> <p class="p2">linear equation derived from this relationship is y=0.1436x+0.7097.</p> <p class="p1">Conclusion: It can be concluded that the present study has provided regression equations for</p> <p class="p1">stature and foot length of an individual that can be used for stature estimation.</p> 2017-07-25T00:00:00+0530 ##submission.copyrightStatement## PROSPECTIVE RANDOMIZED STUDY ON TWO DOSE FRACTIONATION REGIMENS OF HIGH DOSE RATE BRACHYTHERAPY FOR CARCINOMA CERVIX: COMPARISON OF CLINICAL RESPONSE AND COMPLICATIONS IN ORGANS AT RISK 2022-03-28T23:23:05+0530 Saurabh Goswami Piyush Kumar Arvind Kumar Chauhan Jitendra Nigam D. P. Singh <p class="p1">Introduction: Cancer Cervix is treated with a combination of external beam radiotherapy and</p> <p class="p1">intracavitary brachytherapy. With the recent American Brachytherapy Society consensus</p> <p class="p1">guidelines for locally advanced carcinoma of the cervix, atleast Equivalent Dose 2 &gt; 80 Gy for</p> <p class="p1">patients with complete response or partial response with residual disease less than 4cm is</p> <p class="p1">recommended. For non responders or those with tumors larger than 4cm at the time of</p> <p class="p1">brachytherapy, tumor dose escalation to an Equivalent Dose 2 of 85-90 Gy is recommended to</p> <p class="p1">point A. Present study was designed to see the feasibility of these guidelines in terms of local</p> <p class="p1">tumor control and toxicities to rectum and bladder in our group of patients.</p> <p class="p1">Material and Methods: Fifty patients of biopsy proven cancer cervix were enrolled. After</p> <p class="p1">pre-treatment evaluation all patients were delivered external beam radiotherapy 50 Gy in 25</p> <p class="p1">fractions at 200 cGy/day with concurrent cisplatin on weekly basis. Patients were then</p> <p class="p1">randomized into three applications (Group A), four applications (Group B) of HDR</p> <p class="p1">Brachytherapy of 6 Gy each so that total treatment time does not exceed 8 weeks. BED and</p> <p class="p1">LQED were calculated and assessment of response and complications were assessed.</p> <p class="p1">Statistical analysis was done using Chi square test.</p> <p class="p1">Results: Mean age of the patients was 50 years. No significant hematological toxicities and</p> <p class="p1">radiation reactions were seen during external beam radiotherapy. The mean BED of group A</p> <p class="p1">for tumor, rectum &amp; bladder was 137.3 Gy, 112.53 Gy &amp; 103.23 Gy respectively and of group</p> <p class="p1">B was 155.3 Gy, 120.98 Gy and 111.95 Gy respectively. The mean EQD2 in group A at tumor,</p> <p class="p1">rectum &amp; bladder was 74 Gy, 54.08 Gy and 61.94 Gy respectively and in group B was 82 Gy,</p> <p class="p1">59.18 Gy and 66.60 Gy respectively. There was no statistically significant difference in local</p> <p class="p1">response and early &amp; late bladder reactions in both the groups.</p> <p class="p1">Conclusion: In a follow-up of six months we did not find any significant difference in</p> <p class="p1">toxicities of rectum and bladder. Long-term follow-up is needed to see for late rectal and</p> <p class="p1">bladder toxicities.</p> 2017-07-25T00:00:00+0530 ##submission.copyrightStatement## PREVALENCE OF RISK FACTORS AND COMORBID CONDITIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS 2022-03-28T23:23:05+0530 Abhishek Jain Lalit Singh Anurag Agrawal Rajeev Tandon Nipun Agrawal <p class="p1">Introduction: COPD is associated with several risk factors and co morbid conditions. Dealing</p> <p class="p1">with co-morbidity needs a patient centered approach, rather than a disease oriented approach7.</p> <p class="p1">The present study was conducted to study risk factors and co morbid conditions of COPD</p> <p class="p1">patients.</p> <p class="p1">Material and Methods: The present study was conducted in department of Pulmonary</p> <p class="p1">Medicine at Shri Ram Murti Smarak Institute of Medical Sciences with respiratory complaints</p> <p class="p1">over a period of one and a half year. The data was collected in terms of demographic features,</p> <p class="p1">anthropometric measurements and various risk factors and co morbid conditions. Spirometry</p> <p class="p1">was performed thrice and the largest values of both FVC and FEV1 were noted from three</p> <p class="p1">technically satisfactory curves. COPD severity was classified based on Spirometric</p> <p class="p1">assessment according to the GOLD classification. Categorical variables were analyzed using</p> <p class="p1">proportions and percentages.</p> <p class="p1">Results: In a study of 201 cases that were diagnosed as a case of COPD the mean age was 62.6</p> <p class="p1">years and male predominance. Majority of the patients had sedentary life style and were from</p> <p class="p1">poor class. The co morbid conditions anemia, cardiac, hypertension, diabetes mellitus, lipid</p> <p class="p1">disorders, thyroid disorders, osteoporosis, psychiatric illness, ophthalmic defects and</p> <p class="p1">obstructive sleep apnea was found in 43.8%, 52.2%, 65.2%, 52.2%, 51.7%, 64.7%, 72.1%,</p> <p class="p1">66.7%, 28.9% and 54.2% respectively.</p> <p class="p1">Conclusion: Co morbidities should be taken into consideration while prescribing multiple</p> <p class="p1">drugs so that side effects and interactions of drug can be monitored and quality of life can be</p> <p class="p1">improved.</p> 2022-03-28T00:00:00+0530 ##submission.copyrightStatement## RELATION OF HEART WEIGHT WITH AGE AND WEIGHT OF CADAVER 2022-03-28T23:23:05+0530 Jolly Agarwal Virendra Kumar <p class="p1">Introduction: Height, weight, and age of person has significant impact on the normal size of</p> <p class="p1">heart. These parameters need to be considered when cut-off values indicating the need for</p> <p class="p1">treatment or even surgery are established. The aim of present work is to study the relation of</p> <p class="p1">weight of the heart with age and weight of cadaver.</p> <p class="p1">Material and Methods: The study was performed in the Department of Anatomy, Shri Ram</p> <p class="p1">Murti Smarak Institute of Medical Sciences, Bareilly on 30 hearts from embalmed cadavers.</p> <p class="p1">The hearts were procured from the cadavers available in our department. The heart was</p> <p class="p1">thoroughly cleaned and measurements were taken.</p> <p class="p1">Results: The mean heart weight was 223.37 ± 57.78 g. Significant relationship between age of</p> <p class="p1">the cadaver and weight of the heart (p=0.0004), weight of cadaver and weight of heart</p> <p class="p1">(p=0.0001) was observed.</p> <p class="p1">Conclusion: The above study provides valuable data of the heart in our geographical location,</p> <p class="p1">which may be useful for cardiac surgeons and physicians.</p> 2027-07-25T00:00:00+0530 ##submission.copyrightStatement## ORAL MUCOSITIS IN PATIENTS OF HEAD AND NECK CANCERS TREATED WITH CHEMORADIOTHERAPY: ASSOCIATED FACTORS AND TREATMENT OUTCOME 2022-03-28T23:23:05+0530 Manish Kumar Sharma D.P. Singh Piyush Kumar <p class="p1">Introduction: Oral Mucositis develops in nearly all patients receiving radiation therapy for</p> <p class="p1">head and neck cancers. Number of risk factors has been reported to influence the frequency and</p> <p class="p1">severity of Mucositis. The goal of the present study is to evaluate some of the patient and</p> <p class="p1">treatment related factors which make impact on oral mucositis and also to evaluate the impact</p> <p class="p1">of oral Mucositis on treatment outcome.</p> <p class="p1">Material and Methods: Fifty patients were included in this study from July 2014 to June</p> <p class="p1">2016. All the patients were treated with concurrent radiotherapy (70 Gy in 35 fractions in 7</p> <p class="p1">weeks) and chemotherapy (Cisplatin 35 mg/m2 weekly). Clinical Response Assessment was</p> <p class="p1">done as per RTOG Grading and Radiation toxicity was assessed by RTOG Acute &amp; Late</p> <p class="p1">Morbidity Scoring criteria. Statistical analysis was done using Chi Square test and Fischer</p> <p class="p1">Test.</p> <p class="p1">Results: In a patient population of fifty, the intensity of oral Mucositis was correlated with</p> <p class="p1">various patient and treatment related factors. Patient related factors- body mass index ≤18.5</p> <p class="p1">and patients taking tobacco had a higher incidence of Grade III/IV Mucositis (p&lt;0.00 &amp;</p> <p class="p1">p=0.04 respectively). Other factors like age, gender, stage, site of disease and co morbidities</p> <p class="p1">did not show statistical difference in Grade III/IV oral Mucositis. None of the treatment related</p> <p class="p1">factors- total dose of Cisplatin, number of chemotherapy cycles and radiation dose showed</p> <p class="p1">statistical difference in the occurrence of oral Mucositis.</p> <p class="p1">Conclusion: Severe oral Mucositis leads to additional supportive care &amp; even hospitalization.</p> <p class="p1">Targeted interventions need to be developed to reduce the incidence of oral Mucositis.</p> 2017-07-25T00:00:00+0530 ##submission.copyrightStatement## MAGNETIC RESONANCE IMAGING EVALUATION OF SPINAL TUMOURS AND ITS PATHOLOGICAL CORRELATION IN ROHILKHAND REGION 2022-03-28T10:44:36+0530 Taranjeet Kaur Rajneesh Madhok <p class="p1">Introduction: Spinal tumours of the spine constitute around 15-20% of CNS tumours. It can</p> <p class="p1">be localized into three compartments- extradural, intradural extramedullary and</p> <p class="p1">intramedullary. Once the lesion is localized, a differential diagnosis can be established based</p> <p class="p1">on the tumours that commonly occur in that compartment. These lesions have characteristic</p> <p class="p1">magnetic resonance imaging features for a definitive diagnosis. The present study aims to</p> <p class="p1">evaluate spectrum of spinal tumours and correlate MRI imaging with pathological findings.</p> <p class="p1">Material and Methods: The present study included 48 patients and was conducted on 3 Tesla</p> <p class="p1">MRI. The patients who had back pain and neurological symptoms &amp; were diagnosed as spinal</p> <p class="p1">tumours on FNAC/ Biopsy were included. The routine MRI protocols included T1WI &amp; T2WI</p> <p class="p1">sagittal and axial, STIR coronal and sagittal images; slice thickness was 3.0 mm; field of view</p> <p class="p1">(FOV) was 28 - 32 cm and contrast enhanced axial, sagittal and coronal T1W fat sat images.</p> <p class="p1">The images were assessed for location, shape, extent, component characteristics, signal</p> <p class="p1">intensities on different MRI sequences and enhancement patterns of the lesions. The lesions</p> <p class="p1">were correlated with cytohistopathological findings.</p> <p class="p1">Results: Male predominance (2.7:1) with common age group 41-50 years with mean age of 43</p> <p class="p1">years was seen. The male: female ratio in malignant and benign was 1:1.8 and 1:6 respectively.</p> <p class="p1">Most common location of tumours was intradural extramedullary (54.16%), followed by</p> <p class="p1">Extradural (37.5%) and intramedullary spinal cord tumour (6.25%). Most common location</p> <p class="p1">was dorsal (52.08%). The most common spinal tumour was metastasis followed by nerve</p> <p class="p1">sheath tumours. On correlation of MRI finding with cytohistopathology sensitivity and</p> <p class="p1">specificity for malignant lesion was 85.71% and 96.29 % respectively, while for benign lesion</p> <p class="p1">was 96.29 % and 85.71% respectively.</p> <p class="p1">Conclusion: Magnetic resonance imaging is useful in effectively defining the size, shape and</p> <p class="p1">position of tumour along with accurate localization of particular compartment of tumour and</p> <p class="p1">correlation with cytohistopathology.</p> 2017-07-28T00:00:00+0530 ##submission.copyrightStatement## ETIOLOGICAL, CLINICAL AND PATHOLOGICAL PROGNOSTIC MARKERS IN HEAD AND NECK CANCERS TREATED WITH CONCURRENT CHEMO-RADIATION 2022-03-28T23:23:05+0530 Ankur Yadav Piyush Kumar Arvind Kumar Chauhan Milan Jaiswal D. P. Singh <p class="p1">Introduction: Advanced squamous cell carcinoma of head and neck are usually treated with</p> <p class="p1">surgery and/or radiotherapy. Integration of chemotherapy also plays an important role for</p> <p class="p1">improving organ preservation. Various prognostic factors help in selecting the appropriate</p> <p class="p1">treatment regimen for the individual patient. The present study was conducted to identify the</p> <p class="p1">prognostic factors in head and neck cancers.</p> <p class="p1">Material and Methods: Previously untreated 33 patients of squamous cell carcinoma were</p> <p class="p1">selected. They were treated with concurrent chemotherapy and radiotherapy. The response</p> <p class="p1">assessment was analyzed in terms of various patient, tumor and treatment related factors.</p> <p class="p1">Statistical analysis was done using chi square test.</p> <p class="p1">Results: Etiological factors tobacco &amp; alcohol, non-vegetarean diet were associated with a</p> <p class="p1">poor outcome but were not statistically significant. Clinical factors- like higher N-stage</p> <p class="p1">(p=0.04) and AJCC stage (p=0.03) were found to be significant predictors of poor prognosis</p> <p class="p1">while T-stage was not found significant, probably due to short follow-up. Patients receiving</p> <p class="p1">less than 5 cycles of concurrent chemotherapy had a significantly worse prognosis (p=0.04).</p> <p class="p1">Among the pathological factors that were studied, high mitotic index (Grade III or more) were</p> <p class="p1">associated with a significantly poorer prognosis (p=0.04).</p> <p class="p1">Conclusion: Many clinico pathological factors have been correlated with locoregional control</p> <p class="p1">in head and neck cancers. These can be used to individualize the treatment by different surgical</p> <p class="p1">techniques, various radiotherapy dose &amp; fractionation schedules and chemotherapy protocols.</p> 2017-07-25T00:00:00+0530 ##submission.copyrightStatement## BONY TUMOURS OF MAXILLOFACIAL REGION : RETROSPECTIVE STUDY OF CLINICO-PATHOLOGICAL PROFILE AND THEIR MANAGEMENT 2022-03-28T23:23:05+0530 Shubham Dadoo Rohit Sharma Vineet Sharma Annanya Soni <p class="p1">Introduction: Maxillo-facial tumours are a group of heterogenous diseases that ranges from</p> <p class="p1">hamartomas or non-neoplastic tissue proliferations to benign neoplastic to malignant tumors</p> <p class="p1">with metastatic potentials. The aim of the present study is to evaluate the clinico-pathological</p> <p class="p1">profile and management of primary lesions of facio-maxillary region.</p> <p class="p1">Material and Methods: Retrospective data of bony tumors of maxilla-facial region was</p> <p class="p1">retrieved for 2 years from March 2015 to April 2017. The data included the gender, age,</p> <p class="p1">diagnosis based on radiology, histopathology and the site of origin.</p> <p class="p1">Results: A total of 18 patients were diagnosed as a bony tumour of maxillofacial region and</p> <p class="p1">treated surgically. Fibrous dysplasia, Odontogenic cyst and Ameloblastoma were the most</p> <p class="p1">common lesions.</p> <p class="p1">Conclusion: Bony tumours of Maxillofacical region though uncommon and mostly benign,</p> <p class="p1">pose a great challenge to preserve the functions and cosmesis.</p> 2017-07-25T00:00:00+0530 ##submission.copyrightStatement## LEPROSY WITH PSORIASIS A RARE ISOTOPIC PHENOMENON 2022-03-28T23:23:05+0530 Ishita Raka Pratik Gahalaut Nitin Mishra Madhur K. Rastogi <p class="p1">Introduction: Isotopic phenomenon refers to the occurrence of a new dermatosis at the site of previously healed dermatosis. A number of factors including viral, neural, vascular, and immunologic factors have been implicated in the causation of this peculiar phenomenon but none has been proven conclusively. We report a case where leprosy developed at the site of psoriatic lesion previously treated with medical therapy. Case Report: A 50 years old male presented with chief complaints of erythematous, mildly itchy scaly lesions all over the body with a history of relapses and remissions for last 20 years. After confirming the diagnosis of psoriasis with leprosy, patient was managed as an inpatient with oral hypoglycemic drugs along with multibacillary multi drug therapy. For psoriasis, patient was prescribed topical corticosteroids along with emollients over thick scaly lesions. Conclusion: This case has been reported due to the rarity of Wolf's isotopic phenomenon and the coexistence of psoriasis with leprosy. The existing sporadic cases in literature which question the mutually exclusive relationship of leprosy and psoriasis needs further evaluation.</p> 2017-07-25T00:00:00+0530 ##submission.copyrightStatement## RECTAL LYMPHOMA: A RARE CASE REPORT WITH REVIEW OF LITERATURE 2022-03-28T23:23:05+0530 Sunigdha . Manraj S Kang Pardeep Garg Raja P S Banipal Neha Gupta <p class="p1">Introduction: Colorectal lymphoma is an extremely rare disease. The disease is usually</p> <p class="p1">diagnosed in the advanced stages because of its primary nonspecific symptoms. Treatment</p> <p class="p1">modality of primary lymphoma of the rectum remains uncertain.</p> <p class="p1">Case History: A 45-year-old male presented with rectal bleeding, pain in perianal region and</p> <p class="p1">alteration in bowel habits along with fungating and circumferential mass in the rectum. The</p> <p class="p1">histopathology and immunohistochemistry confirmed the diagnosis of Plasmablastic</p> <p class="p1">Lymphoma. He was planned six cycles of CHOP regime. On follow up the residual disease was</p> <p class="p1">managed with second line of chemotherapy (DHAP regimen). The patient was started on</p> <p class="p1">Metronomic chemotherapy (Chlorambucil &amp; Etoposide) in view of persistent residual disease.</p> <p class="p1">Conclusion: Optimal treatment for rectal lymphoma needs to be established.</p> 2017-07-25T00:00:00+0530 ##submission.copyrightStatement##