SRMS JOURNAL OF MEDICAL SCIENCE <p>The SRMS Journal of Medical Sciences (SRMSJMS) is a biomedical journal with national circulation. It publishes original communications of biomedical research that advances or illuminates medical science or that educates the journal readers. It is issued six monthly, in two volumes per year.&nbsp;Manuscripts dealing with clinical aspects will be considered for publication, provided they contain results of original investigations. Articles need to be of general interest - e.g., they cross the boundaries of specialities or are of sufficient novelty and importance that the journal's readers, whatever their speciality, should be made aware of the findings. Research papers reporting original research, review articles, correspondence on published articles will also be considered. Papers of routine nature which are merely records of interesting cases as also those dealing with modifications of routine methodology will not be encouraged.</p> <div class="page-header"> <h1>Article Processing Fee/Open Access Fee</h1> </div> <p><strong>Author Fee</strong></p> <p>Indian Journal of Pharmaceutical and Biological Research is an open access journal, and then Author submission, as well as article processing and publishing, is&nbsp;<strong>free of charge</strong>.</p> <p>Readers can read and download any full-text articles for&nbsp;<strong>free of charge</strong>.</p> en-US (Pradeep Tiwari) Fri, 30 Dec 2022 00:00:00 +0530 OJS 60 To Study the Vaginal Cytological Changes in Term Pregnant Women and to Determine its role in Predicting the Onset of Labor <p>Introduction: To study the vaginal cytological changes in<br>pregnant women and to determine its diagnostic accuracy in<br>predicting the onset of labor.<br>Material and methods: This prospective case study was<br>conducted in the Department of Obstetrics and Gynecology,<br>SRMS IMS, Bareilly on 100 antenatal patients admitted at term<br>(37–42 weeks). Vaginal cytology was studied in subjects in the<br>pre-labor stage and these subjects were followed in early labor.<br>Results: As the gestation period increases, there is an<br>alteration in vaginal cytology under hormonal change. Due<br>to a decrease in progesterone hormone at term, the number<br>of intermediate cells decreases and that of superficial cells<br>increases under the effect of estrogen hormone. Cluster cells<br>also decrease. The sensitivity and specificity of superficial<br>cells was 76.25 and 45%, respectively in predicting labor onset<br>within 3 days.<br>Conclusion: Progesterone</p> Vishakha Choudhary, Mridu Sinha, Shashibala Arya, Shubhangi Gupta ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Propylthiouracil Induced Neurotoxicity in Swiss Albino Mice Fetus <p>Introduction: Anti-thyroid drugs are used to treat hyperthyroidism in pregnancy, as pregnancy-associated hyperthyroidism causes fetal and maternal complications. Propylthiouracil is recommended for the treatment of hyperthyroidism in the first trimester, though limited reports of congenital anomalies are associated with its antenatal usage.<br>Aim: The present study aims to reveal the teratogenicity of propylthiouracil by studying its neurotoxic effect in mice fetuses.<br>Material and Methods: Propylthiouracil was orally administered in a dose of 100 mg/kg body weight/day to pregnant Swiss albino mice during the period of organogenesis (treated group), while pregnant dams of control group were given distilled water orally (same volume and for same duration). The pregnancy was terminatedon the 18th day of conception after sacrificing the pregnant dams and fetuses were collected. The fetal brains (from both, control and treated groups) were dissected out, examined and processed for further histological study.<br>Results: The brains of the treated group shows hemorrhagic spots on gross examination, while microscopic examination shows degeneration in the hippocampal area, degenerated<br>choroid plexus and dilatation of lateral and fourth ventricles along with the destruction of ependymal lining of these ventricles. No such findings are present in brain of control<br>group.<br>Conclusion: The safety of propylthiouracil must be re-evaluated through large randomised clinical trials, as it is observed to have neurotoxic effect on mice fetus in the present study</p> Samta Tiwari, Neel Kamal Arora, S. K. Pandey ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Adverse Childhood Experiences and Harmful Health Behaviour among Youth: A Cross-sectional Study in Western Uttar Pradesh <p>Adverse childhood experiences (ACEs) are quite<br>common and significantly affect adolescent health, reproductive<br>health, smoking, alcoholism, illicit drug use, sexual behaviour,<br>mental health, and job performance. The present study aims<br>to determine how prevalent ACE are among youth and the<br>prevalence of harmful behaviour among research participants.<br>Further determine the correlation of ACE with the harmful<br>behaviour among study participants.</p> Huma Khan, Ravi Kumar, Abhinav Pandey ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Setup Errors in Interfraction Radiotherapy in Patients of Head and Neck Cancer <p>Reproducibility of daily position is necessary for<br>efficacious delivery of radiotherapy. There are uncertainties<br>during the delivery of radiotherapy which increases the risk of<br>inadequate dose delivery to the target as well as unnecessary<br>irradiation of nearby normal tissues. These uncertainties, known<br>as setup errors, should be clinically in order to attain optimum<br>planning target volume (PTV) margins. The present study aims<br>to find out the optimum PTV margins in our department with<br>existing immobilization system and imaging facilities.</p> R Yadav, AK Chauhan, P Kumar, P Kumar, J Nigam, NS Silambarasan ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Estimation of serum bile acid level for diagnosis of intrahepatic cholestasis of pregnancy, and its correlation with maternal and fetal outcome <p>Intrahepatic cholestasis of pregnancy is a<br>disease characterized by pruritis over limbs associated with<br>increased level of liver enzymes seen in the second and/<br>or third trimester after ruling out other causes. Incidence of<br>intrahepatic cholestasis of pregnancy varies widely, ranging<br>from &lt; 1 to 27.6%. It causes adverse effects on the maternal<br>outcome, fetal, and/or neonatal outcome</p> Arushi Aggarwal, Mridu Sinha, Tariq Mahmood, Shanti Sah, Gulafshan Anjum ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Dose Escalation by Intraluminal Brachytherapy in Cancer Esophagus – A Retrospective Audit <p>Introduction- Chemoradiation (CRT) in esophageal cancer as a definitive modality of treatment has shown an increasing trend of utilization over surgical modalities. Local failures after chemoradiotherapy have led to the concept of radiation dose escalation, but simultaneously it leads to the concerns of radiation related toxicities of strictures and fistulas. Considering this fact dose escalation with intraluminal brachytherapy seems and optimal option. The present study retrospectively analyzed the safety and efficacy of using ILBT as a boost after external beam radiotherapy.<br>Materials and Methods- Records of patients with Esophageal Carcinoma (EC) registered in the radiotherapy department between December 2008 to June 2016 were retrospectively<br>analyzed. Data was collected on patient, tumor and treatment characteristics and patient outcomes. The toxicitieshematological or radiation-induced were documented. The<br>response assessment after treatment and survival parameters were analyzed. Univariate and multivariate analyses were done for survival parameters. Statistical significance was considered if p-value was less than 0.05.<br>Results- A total of 69 patients were eligible for the present analysis. Male to female ratio 1.09:1, with median age of 60 years. The common primary side was the middle 1/3rd esophagus. The mean tumor length was 6.4cm and all patients had squamous cell carcinoma. EBRT dose of 59.4 Gy was received 94.2% of patients, 13 (18.8%) received ILRT radiotherapy with 6Gy in a single setting. The median concurrent chemotherapy administered were 5. Grade 3 and 4 acute hematological toxicities were seen in terms of anemia (7.2%), leucopenia (18.8%) and thrombocytopenia (1.4%). Stenosis was seen in 40.6% of patients among which only 13 patients required dilatation. Nine of the patients receiving intraluminal brachytherapy (ILBT) developed fistula. The compete response was better in ILBT group (84.61 vs 57.49%, p=0.07). The median overall survival for all patients was 15 months. Overall&nbsp; survival was increased in patients of ILBT group (41 months versus 12 months, p=0.005).<br>Conclusion- ILBT has the advantage of high precision and avoidance of dose to critical structures which could be optimally used for dose escalation in patients of cancer esophagus.</p> Richa Gupta, Piyush Kumar, Ankita Mehta, Ayush Garg, Shubhi Agarwal ##submission.copyrightStatement## Fri, 30 Dec 2022 00:00:00 +0530 Computed Tomography Evaluation of Spontaneous Intracranial Hemorrhages <p>To d escribe t he e tiology a nd s pectrum o f fi ndings o n<br>computed tomography in patients with spontaneous intracranial<br>hemorrhages and study the correlation of volume and site of<br>intracranial hemorrhages with clinical outcome at the time of<br>discharge.</p> Satyarth Singh, Sameer R Verma, Rashmi Rekha, Shashank Sah ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Diagnostic Utility of Fractional Exhaled Nitric Oxide Findings in Patients of Asthma, COPD and Asthma and COPD Overlap <p>Asthma, COPD and COOP Overlap Syndrome<br>are among the most prevalent chronic disorders affecting the<br>general population. The study was intended to understand the<br>diagnostic utility of Fractional Exhaled Nitric Oxide (FeNO)<br>testing in Asthma, COPD and Asthma COPD Overlap syndrome<br>patients.</p> Yasmoon A. Siddiqui, Rajeev Tandon, Lalit Singh, Pradeep Nirala ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Spectrum of Skin Dermatoses among Patients of Substance Use Disorder: A Hospital-based Study <p>Introduction: Various substances of abuse are known to cause specific cutaneous manifestations. Cutaneous manifestations are associated with the use of cocaine, methamphetamine, heroin, marijuana, alcohol, anabolic steroids, and general signs of drug abuse, including the stigmata of injection drug use, infectious complications, and vascular complications. However, the literature on the same is very limited from the Indian subcontinent. The purpose of the study is to find out various dermatoses in patients of substance use disorder.<br>Materials and Methods: In the present study, 46 Diagnosed cases of substance use disorder as per the Diagnostic and statistical manual of mental disorder-5 (DSM-5)1 and confirmed by a qualified psychiatrist, were taken. The cutaneous examination was performed accordingly. Laboratory investigations were done as per need.<br>Results: Mean age was 42.21 ± 16.64. The majority of the patients were illiterate (41.3%) and 26.1% were either graduate or postgraduate and 21.7% were high school pass and 6.5%<br>were in middle school and the minority had primary school education (4.3%). The majority of the patients had complaints of raised lesions (56.5%) and followed by redness (23.9%), pain (19.6%), burning (13%) and oozing (13%) discomfort and flaking of skin (10.9%), rash (8.7%), light spots (6.5%) and fluid-filled lesions (4.3%).<br>Conclusion: Few substances were associated with specific dermatoses. However, there is very little data, so this study will add upon the minuscule literature on this topic.</p> Vishvajot ., Pratik Gahalaut, Madhur K Rastogi, Deepak Charan ##submission.copyrightStatement## Fri, 30 Dec 2022 00:00:00 +0530 Health Benefits in a New Era of Medicine: Probiotics as Nutraceutical <p>We are aware of the function and needs of the six major<br>nutrients found in food: water, vitamins, minerals, fats, proteins,<br>and carbs. In addition to these elements, foods also include<br>other vital nutrients that are required for good health and are<br>increasingly popular. The idea of "functionality" was inspired<br>by this comprehensive view of nutrition. Due to its potential for<br>having beneficial nutritional, safe, therapeutic, and effective<br>impacts, nutraceuticals have recently gained a lot of attention.<br>They might be involved in biological activities like gene<br>expression, antioxidant defenses, cell division, and upkeep of<br>the mitochondria's integrity. Nutritional supplements are used<br>to boost immunity, prevent chronic diseases, slow down the<br>aging process, and ultimately raise.</p> Dipali Gupta, Nipun Agrawal, Shubhi Saxena, Shivang Saxena ##submission.copyrightStatement## Wed, 19 Apr 2023 00:00:00 +0530 Intensity Modulated Radiotherapy in a Rare Case of Spinal Glioblastoma Multiforme: A Case Report <p>Primary spinal cord glioblastoma multiforme<br>(GBM) is a rare clinical entity with an aggressive course and<br>an invariably dismal prognosis. There are around 200 reported<br>cases of spinal cord GBM in total and approximately 70 cases<br>in the cervical region. Median survival for this disorder is only<br>12 months. We report a case of a 36 year old female patient<br>with primary spinal cord GBM.</p> Karishma Agarwal, Ayush Garg, Piyush Kumar, Ruchee Khandelwal, Shashank Sah, Sameer R. Verma ##submission.copyrightStatement## Fri, 30 Dec 2022 00:00:00 +0530