COMPARATIVE STUDY OF EFFICACY OF HYOSCINE BUTYLBROMIDE AND DROTAVERINE FOR AUGMENTATION OF LABOR

Abstract

Introduction: Prolonged labour contributes to increased perinatal and maternal
morbidity.Various drugs have been tried to hasten the cervical dilatation. The ultimate aim of
the obstetrician is to accomplish the delivery in the shortest possible time without
compromising maternal and fetal safety. This study aims to compare the efficacy of Hyoscine
Butyl Bromide with Drotaverine Hydrochloride for augmentation of labor.
Material and Methods: This was a prospective study conducted on 120 women with term
gestation; in active labor. The patients were chosen by simple randomization and were divided
into 3 groups- A, B and C respectively of 40 patients each. Group A received intramuscular
injection drotaverine hydrochloride one ampule (40 mg), group B received intramuscular
injection hyoscine butylbromide (20 mg) and group C which was control group, received no
drug.
Results: The mean rate of cervical dilatation with buscopan was 2.23cm/hr while it was
2.03cm/hr and 2.08cm/hr in drotaverine group and control group respectively. Thus the drug
delivery interval was less in buscopan group. Mean duration of active phase of first stage of
labor was 156.13 minutes in buscopan group against 181.25 minutes in drotaverine group
though buscopan was found to have less effect on duration of second stage of labor.
Conclusion: Buscopan was found to be an effective and safe drug in shortening the duration of
first stage of labor without any significant detrimental effects on the mother and newborn
thereby minimizing maternal and fetal morbidity.