Evaluation of Immunohistochemical Expression of Cyclin D1 and its Clinicopathological Correlation in Oral Carcinoma

Abstract

Introduction: The present study aimed to evaluate the expression of cyclin D1 in oral carcinoma and to find the association of the expression of cyclin D1 with different histological types, grades and other clinicopathological findings. Materials and Methods: A 50 formalin fixed paraffin embedded tumor sections, stained with haematoxylin & eosin were graded and immunohistochemistry for cyclin D1 evaluated as expression score (ES), intensity score (IS) and total score (TS) was calculated. Results: A significant association was seen between total score of cyclin D1 expression with tumor types squamous cell carcinoma (Grade 1 and Grade 2) and verrucous carcinoma. Conclusion: In the present study for cyclin D1 evaluation, its expression was found in all oral carcinoma cases. A strong association was found between cyclin D1 total score with squamous cell carcinoma (Grade 1 and Grade 2) and verrucous carcinoma. We did not find a significant association between cyclin D1 total score and age, gender, tumor grades, site, laterality, PNI, LVI, pathological and clinical staging.