Effect of Platelet-Rich Plasma Therapy on Radiological and Electrophysiological Parameters of the Ulnar Nerve in Patients of Leprosy: A Hospital-Based Prospective Comparative Study

Abstract

Introduction: Leprosy, a chronic disease caused by Mycobacterium leprae, often leads to ulnar neuropathy, causing sensory and motor impairments. Despite treatment, nerve damage may persist, and regenerative therapies like plateletrich plasma (PRP) are being explored for their potential to enhance nerve regeneration. Material and Methods: This prospective study aimed to evaluate PRP therapy’s effects on ulnar neuropathy in leprosy patients. Conducted at Shri Ram Murti Smarak Institute of Medical Sciences, it included 24 patients with bilateral thickened ulnar nerves. PRP was injected into one ulnar nerve while the other received a sham saline injection. Sensory testing, nerve conduction studies, and ultrasound measurements of the ulnar nerve were performed pre- and post-procedure. Results: Sensory and motor parameters showed no significant differences between PRP-treated cases and controls. Sensory function deteriorated more in some cases, but changes in monofilament values, latency, velocity, and amplitude were not statistically significant. A significant reduction in the ulnar nerve area was observed post-procedure, but the overall change and percentage change were not significant. Conclusion: PRP therapy demonstrated a minimal impact on nerve function in leprosy-induced ulnar neuropathy. Further studies are needed to confirm its potential clinical relevance.